The β-site amyloid precursor protein (APP)-cleaving enzyme 1 (β-secretase BACE1) initiates amyloidogenic processing of APP to generate amyloid β (Aβ) which is a hallmark of Alzheimer disease (AD) pathology. whereas the RNAi knockdown of endogenous Rheb promotes BACE1 accumulation and this effect by Rheb is independent of its mTOR signaling. Moreover GTP-bound Rheb interacts with… Continue reading The β-site amyloid precursor protein (APP)-cleaving enzyme 1 (β-secretase BACE1) initiates