In individuals with acute promyelocytic leukemia (APL), ~98% express the promyelocytic leukemia (PML)-retinoic acid receptor (RAR) fusion protein. transfected NLS-RAR in NB4 cells, puromycin was used to select the stable transfected cell lines. Cell Counting Kit-8 and circulation cytometry analysis revealed the efficient overexpression of NLS-RAR significantly advertised NB4 cell proliferation and inhibited all-trans retinoic… Continue reading In individuals with acute promyelocytic leukemia (APL), ~98% express the promyelocytic
Tag: neutrophils
Background Proline-rich tyrosine kinase 2 (Pyk2) is vital in neutrophil degranulation
Background Proline-rich tyrosine kinase 2 (Pyk2) is vital in neutrophil degranulation and chemotaxis in vitro. static lung compliance was determined by pressure-volume curve using a computer-controlled small animal ventilator. The extravasated Evans blue concentration in lung homogenate was determined spectrophotometrically. Results Intratracheal instillation of LPS induced significant neutrophil infiltration into the lung interstitium and alveolar… Continue reading Background Proline-rich tyrosine kinase 2 (Pyk2) is vital in neutrophil degranulation