We synthesized 5-substituted pyrrolo[2 3 nucleotide biosynthesis because the targeted pathway. suppresses nucleotide biosynthesis leading to an imbalance of purine and pyrimidine precursors making cells not capable of going through accurate DNA replication eventually leading to cell death. Clinically relevant TS and DHFR inhibitors typified by pemetrexed (PMX) TPEN and methotrexate (MTX) and pralatrexate (Figure… Continue reading We synthesized 5-substituted pyrrolo[2 3 nucleotide biosynthesis because the targeted pathway.