To explore the molecular mechanisms by which glioblastomas are resistant to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), we examined TRAIL signalling pathways in the tumours. DISC was altered by receptor-interacting protein (RIP), TP-434 manufacturer cellular FADD-like interleukin-1-converting enzyme inhibitory protein (c-FLIP) and phosphoprotein enriched in diabetes or in astrocyte-15 (PED/PEA-15). This DISC modification occurred in… Continue reading To explore the molecular mechanisms by which glioblastomas are resistant to