High-mobility group box 1 (HMGB1) triggers and amplifies inflammation cascade following ischemic injury and its elevated levels are associated with adverse clinical outcomes in patients with myocardial infarction (MI). expression of HMGB1 RAS components and inflammatory cytokines. ACE2 in the heart of the ACE2 KI mice was 58-fold higher than WT controls. ACE2-MI mice exhibited… Continue reading High-mobility group box 1 (HMGB1) triggers and amplifies inflammation cascade following