Phosphorylated residues occur preferentially in the intrinsically disordered regions of eukaryotic proteins. vitro. However molecular dynamics simulations predicted that Tyr31 is mostly buried and that phosphorylation of Tyr4 would increase the solvent exposure and thus kinase convenience of Tyr31. In fibroblast cells EGF activation increased tyrosine phosphorylation of a mutant form of ACTN4 with a… Continue reading Phosphorylated residues occur preferentially in the intrinsically disordered regions of eukaryotic