Methylation of the arginine residues of histones by methyltransferases has important consequences for chromatin structure and gene regulation; however the molecular mechanism(s) of methyltransferase regulation is still unclear as is the biological significance of methylation at particular arginine residues. acid) binds to the substrate (histone) preferentially at the signature motif “KAPRK ” where the proline… Continue reading Methylation of the arginine residues of histones by methyltransferases has important