Background Medulloblastoma is a highly malignant pediatric brain tumor that requires surgery, whole brain and spine irradiation, and intense chemotherapy for treatment. high constitutive activity of the canonical NFB pathway, as seen by Western analysis of the NFB subunit p65, in medulloblastoma tumors compared to normal brain. The p65 subunit of NFB is usually extremely… Continue reading Background Medulloblastoma is a highly malignant pediatric brain tumor that requires
Tag: BMY 7378
Methylation of the arginine residues of histones by methyltransferases has important
Methylation of the arginine residues of histones by methyltransferases has important consequences for chromatin structure and gene regulation; however the molecular mechanism(s) of methyltransferase regulation is still unclear as is the biological significance of methylation at particular arginine residues. acid) binds to the substrate (histone) preferentially at the signature motif “KAPRK ” where the proline… Continue reading Methylation of the arginine residues of histones by methyltransferases has important