Supplementary MaterialsData_Sheet_1. TCRs that understand type 1 diabetes-related autoantigens with the purpose of tissue-targeted induction of antigen-specific tolerance to prevent -cell damage. We generated human being Tregs expressing a high-affinity GAD555C567-reactive TCR (clone R164), aswell as the low affinity clone 4.13 specific for the same peptide. We proven that Treg avatars potently suppress antigen-specific and… Continue reading Supplementary MaterialsData_Sheet_1. TCRs that understand type 1 diabetes-related autoantigens with the