The PDGF family are potent mitogens for cells of mesenchymal origin and serve as important regulators of cell migration survival apoptosis and transformation. of cleaving PDGF-C to its active form. Increased PDGF-C expression enhances cell proliferation anchorage independent cell growth and tumor cell motility by autocrine signaling. In addition MCF7-produced PDGF-C induces fibroblast cell migration… Continue reading The PDGF family are potent mitogens for cells of mesenchymal origin