Purpose ABCG2 overexpression has been linked to resistance to topoisomerase inhibitors leading us to examine the potential interaction between ABCG2 and becatecarin. antibody 5D3 compared to parental cells. Increased ABCG2 expression was confirmed NOX1 by immunoblot. Conclusions Our results suggest that becatecarin is transported by ABCG2 and can induce ABCG2 expression in cancer cells. and… Continue reading Purpose ABCG2 overexpression has been linked to resistance to topoisomerase inhibitors