Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. human breast cancer cells and patient tumors. Ectopic overexpression of KLF8 in the non-invasive MCF-10A cells induced the EPSTI1 expression whereas KLF8 knockdown from the invasive MDA-MB-231 cells decreased the EPSTI1 expression. Promoter activation and binding analyses LY 2183240 indicated… Continue reading Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic