Large affinity substrate-trapping protein tyrosine phosphatases have been widely used both to investigate the endogenous targets of many phosphatases and to address questions of substrate specificity. were catalytically inactive but showed high affinity for an important tyrosine kinase in T cells that Sts-1 is known to regulate Zap-70. Sts-1 substrate-trapping mutants isolated tyrosine-phosphorylated Zap-70 from… Continue reading Large affinity substrate-trapping protein tyrosine phosphatases have been widely used both