is reported to become naturally resistant to trimethoprim (TMP), a medication that inhibits dihydrofolate reductase (DHFR), an integral enzyme in the folate pathway. cells changed using the Sterne DHFR gene. Positioning from the amino acidity sequence from the Sterne DHFR gene exposed 100% homology with numerous virulent strains of to TMP and clarify that this… Continue reading is reported to become naturally resistant to trimethoprim (TMP), a medication