Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s disease (Advertisement) nevertheless the intrinsic link between tau accumulation and cholinergic deficits is definitely lacking. by selective calpain-2 inhibitor however not calpain-1 attenuated the hTau-induced degradation of α4 nAChR. Finally we proven that hTau build up improved the basal intracellular calcium mineral level in… Continue reading Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s