Supplementary Materials Data Supplement supp_1_3_e22__index. for late-onset Alzheimer disease (AD) is the apolipoprotein E gene (4 allele carrying the greatest risk via effects on -amyloid (A) metabolism.1 codes for the apolipoprotein E protein (apoE), which plays an essential role in cholesterol metabolism, neuronal trafficking, synaptogenesis, and bloodCbrain barrier integrity.1,2 ApoE-containing lipoproteins bind A and promote… Continue reading Supplementary Materials Data Supplement supp_1_3_e22__index. for late-onset Alzheimer disease (AD) is