We previously showed the herpes simplex virus 1 (HSV-1) tegument protein VP11/12 activates the lymphocyte-specific Src family kinase (SFK) Lck and is tyrosine phosphorylated in an Lck-dependent manner during T cell illness. and main fibroblasts. VP11/12 interacts with PI3K or PI3K signaling complexes during illness suggesting that VP11/12 activates PI3K directly. SFK activity is required… Continue reading We previously showed the herpes simplex virus 1 (HSV-1) tegument protein