Insulin-like growth factor (IGF) system plays important roles in carcinogenesis and maintenance of the malignant phenotype. phosphatidylinositol 3-kinase and mitogen-activated protein kinase were involved in IGF-I induction of SNCG expression. Interestingly SNCG knockdown led to proteasomal degradation of IGF-IR thereby decreasing the steady-state levels of IGF-IR. Silencing of SNCG resulted in a decrease in ligand-induced… Continue reading Insulin-like growth factor (IGF) system plays important roles in carcinogenesis and