T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subset of Clemastine fumarate acute leukemia characterized by frequent activation of Notch1 or AKT signaling where new_therapeutic approaches are needed. kinase-inactive (K43M) CDK6 are resistant to induction of T-ALL by activated Notch whereas those expressing INK4-insensitive (R31C) CDK6 are permissive. Pharmacologic inhibition of CDK6 kinase induces CD25… Continue reading T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subset of