Aims To characterize determinants of the elimination of methotrexate (MTX) and 7-hydroxy-methotrexate (7-OH-MTX) in patients receiving high-dosage MTX therapy (HDMTX). reduction in CLMTX and a 38% reduction in CL7-OH-MTX. Plasma MTX concentrations had been considerably higher in individuals also getting benzimidazoles at 24 h (2.01 mol L?1 0.66 mol L?1, 10?4) and in 48 h… Continue reading Aims To characterize determinants of the elimination of methotrexate (MTX) and