The spindle assembly checkpoint (SAC) monitors and promotes kinetochore-microtubule attachment during mitosis. immediate hetero-dimerization with Bub1 at a pseudo-symmetric user interface. This pseudo-symmetric relationship underpins a template-copy romantic relationship essential for kinetochore-microtubule connection and SAC signaling. Our results illustrate how gene duplication and sub-functionalization shape the workings of an essential molecular network. DOI: http://dx.doi.org/10.7554/eLife.05269.001 (Primorac… Continue reading The spindle assembly checkpoint (SAC) monitors and promotes kinetochore-microtubule attachment during