Supplementary Materials Supplemental Data supp_27_8_2277__index. also elevated in the macrophages of diabetic miR-146a?/? mice. These studies suggest that in early DN, miR-146a upregulation exerts a protective effect by downregulating target inflammation-related genes, resulting in suppression of proinflammatory and inflammasome gene activation. Loss of this protective mechanism in miR-146a?/? mice leads to accelerated DN. Taken together,… Continue reading Supplementary Materials Supplemental Data supp_27_8_2277__index. also elevated in the macrophages of