Supplementary Materials1. results imply that fusion gene offers raised further questions about induced leukemogenesis. We generated knock-in mice expressing a CBF-SMMHC mutant lacking the HABD in the SMMHC tail. As a result, the mutant CBF-SMMHC offers lower RUNX1 binding affinity20. Unexpectedly, these mice showed accelerated leukemogenesis. We also generated knock-in mice having a deletion mutant… Continue reading Supplementary Materials1. results imply that fusion gene offers raised further questions