The unique phenotypic characteristics of mammalian prions are thought to be encoded in the conformation of pathogenic prion proteins (PrPSc). the competitive selection of those with lower initial conformational stability. In serial propagation with a nonglycosylated mutant PrPC substrate the dominant PrPSc conformers are subject to further evolution by natural selection of the subpopulation with… Continue reading The unique phenotypic characteristics of mammalian prions are thought to be
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The UNited RESidue (UNRES) coarse-grained model of polypeptide chains developed in
The UNited RESidue (UNRES) coarse-grained model of polypeptide chains developed in our laboratory enables us to carry out millisecond-scale molecular-dynamics simulations of large proteins effectively. launched new side-chain-backbone correlation potentials derived from a statistical analysis of loop regions of 4585 proteins. To obtain sufficient statistics we reduced the set of amino-acid-residue types to five organizations… Continue reading The UNited RESidue (UNRES) coarse-grained model of polypeptide chains developed in