is expressed in hematopoietic stem and progenitor cells although this expression is usually diminished as these cells undergo differentiation. disruption of this gene impairs normal hematopoietic proliferation and repopulation [7, 8]. A role for in the development of acute myeloid leukemia (AML) was initially recognized in mice. Using retroviral insertional mutagenesis, is overexpressed in about… Continue reading is expressed in hematopoietic stem and progenitor cells although this expression