Zoom lens epitheliumCderived growth factor (LEDGF/p75) is a cellular cofactor of HIV-1 integrase (IN) that interacts with IN through its IN binding domain (IBD) and tethers the viral pre-integration complex to the host cell chromatin. results further support the potential of LEDGINs as allosteric integrase inhibitors. Author Summary Like other viruses, HIV has a limited… Continue reading Zoom lens epitheliumCderived growth factor (LEDGF/p75) is a cellular cofactor of