Germ series mutations of the ubiquitin ligase cullin 7 (CUL7) are linked to 3-M syndrome and Yakuts short stature syndrome both of which are characterized by pre- and post-natal growth retardation. CUL7 levels in term trophoblast cells or JEG-3 cells which are derived from human choriocarcinoma but exhibit weak invasion capacity were low or undetectable.… Continue reading Germ series mutations of the ubiquitin ligase cullin 7 (CUL7) are