The tight junction (TJ) is the major determinant of paracellular permeability which in the gut protects the body from entry of harmful substances such as microbial components. correctly localized to the TJ principally in the crypts which are enlarged in CF. The cytokine TNFα known to affect TJ was elevated to 160% of wild type… Continue reading The tight junction (TJ) is the major determinant of paracellular permeability