Supplementary Materialsoncotarget-09-5931-s001. the normal pancreas. SEMA5A expression was localized on tumor cells with no staining in the surrounding stroma. To understand the functional significance of SEMA5A, we treated PC cell lines with recombinant SEMA5A. We observed an increase in migration, chemotaxis, and scattering of PC cells. To delineate the signaling axis of SEMA5A, we generated… Continue reading Supplementary Materialsoncotarget-09-5931-s001. the normal pancreas. SEMA5A expression was localized on tumor
Tag: S1PR2
Objective: We examined a cohort of Australian sufferers with statin exposure
Objective: We examined a cohort of Australian sufferers with statin exposure who developed a necrotizing autoimmune myopathy (NAM) associated with a novel autoantibody against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and describe the clinical and therapeutic difficulties of managing these individuals and an optimal therapeutic strategy. steroid therapy, with 5 relapsing upon efforts to wean steroids. Both… Continue reading Objective: We examined a cohort of Australian sufferers with statin exposure
Enzymes use a number of common cofactors as sources of hydrogen
Enzymes use a number of common cofactors as sources of hydrogen to drive biological processes but the physics of the hydrogen transfers to and from these cofactors is not fully understood. of two case studies. The first example is alcohol dehydrogenase which uses a nicotinamide cofactor to catalyze a hydride transfer and the second example… Continue reading Enzymes use a number of common cofactors as sources of hydrogen