The evidence that nuclear proteins can be degraded by cytosolic proteasomes has received considerable experimental support. its interaction with Srp1 and caused proteasome mislocalization. In agreement with this observation a mutation in Srp1 that weakened its interaction with Sts1 also reduced nuclear targeting of proteasomes. We reported that Sts1 could suppress growth and proteolytic defects… Continue reading The evidence that nuclear proteins can be degraded by cytosolic proteasomes