An orally bioavailable and blood-brain hurdle penetrating analog of the kinase inhibitor K252a was able to prevent the standard engine deficits in the tau (P301L) transgenic mouse magic size (JNPL3) and markedly reduce soluble aggregated hyperphosphorylated tau. a critical role in the development of tauopathy and suggest a previously undescribed treatment strategy for neurodegenerative diseases… Continue reading An orally bioavailable and blood-brain hurdle penetrating analog of the kinase