Supplementary MaterialsSupplemental Digital Content. PNGS mutants, just 197M.1 (N197D/N301Q) shed infectivity completely, while others (aside from 197M.6) showed reduced viral infectivity. With regards to neutralization awareness to known nMAbs, we discovered that adding N463Q mutation to all or any the gp120 mutants formulated with N197D significantly elevated neutralization awareness to VRC01 and VRC03, recommending N197… Continue reading Supplementary MaterialsSupplemental Digital Content. PNGS mutants, just 197M.1 (N197D/N301Q) shed infectivity