In cardiac ischemia-reperfusion injury, reactive air species (ROS) generation and upregulation of the hypoxia-inducible protein BNIP3 result in mitochondrial permeabilization, but impairment in autophagic removal of damaged mitochondria provokes programmed cardiomyocyte loss of life. loss of life. On the other hand, overexpression of beclin-1 activates mTOR to lessen TFEB, ensuing in diminishes in lysosome reductions… Continue reading In cardiac ischemia-reperfusion injury, reactive air species (ROS) generation and upregulation