The Murine Two times Minute 2 (MDM2) protein is a key regulator of cell proliferation and apoptosis that acts primarily by inhibiting the p53 tumor suppressor. 4E (eIF4E) efficiently abolishes IGF-1-mediated up-regulation of MDM2. In addition we show that rapamycin effectively inhibits MDM2 expression and sensitizes cancer cells to chemotherapy. Taken together this study reveals… Continue reading The Murine Two times Minute 2 (MDM2) protein is a key