Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a multitude of tumors, whereas activating Wnt pathway mutants are located in cancer of the colon. by activation from the PI3K/PKB pathway. Intro Developmental signaling cascades typically transduce signals from the cell surface onto regulatory sequences of nuclear target genes. In the simplest model, signals… Continue reading Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a