High grade serous ovarian carcinoma (HGSC) is a DNA instable tumor and its precursor is commonly found originating from the fimbriated end of the fallopian tube secretory epithelial (FTSE) cells. premature senescence (SIPS). However ROS-induced miR-182 is regulated by β-catenin not by p53. In normal FTSE cells miR-182 overexpression triggers cellular senescence by p53-mediated upregulation… Continue reading High grade serous ovarian carcinoma (HGSC) is a DNA instable tumor