The INhibitor of Development (ING) proteins become type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. ING1a to stimulate a senescent phenotype, confirming that ITSN2 is normally a significant transducer of ING1a-induced senescence signaling. These data recognize a pathway where ING1a induces senescence and suggest that modified… Continue reading The INhibitor of Development (ING) proteins become type II tumor suppressors
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Aminoacyl-tRNA synthetases catalyze the first step of protein synthesis. that consists
Aminoacyl-tRNA synthetases catalyze the first step of protein synthesis. that consists of the aminoacylation of tRNAs. Recently we shown that one of the tRNA synthetases-human tyrosyl-tRNA synthetase (TyrRS)-offers novel cytokine functions in addition to its part in protein synthesis (1). This demonstration founded a link between protein synthesis and transmission transduction. Under apoptotic conditions in… Continue reading Aminoacyl-tRNA synthetases catalyze the first step of protein synthesis. that consists