Supplementary Materialsmbc-30-268-s001. possible HCM-causing mechanisms from the R21H mutation can be through alteration of leiomodins function. Intro Many missense mutations in Tpm1.1, the predominant tropomyosin (Tpm) isoform in striated muscle tissue, are Nelarabine novel inhibtior associated with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) (Redwood and Robinson, 2013 ). DCM can be seen as a… Continue reading Supplementary Materialsmbc-30-268-s001. possible HCM-causing mechanisms from the R21H mutation can be