Supplementary MaterialsSupplementary Data 41598_2017_5667_MOESM1_ESM. improved in OLETF. Treatment of OLETF with rapamycin, an mTORC1 inhibitor, partially restored autophagic activation in response to I/R and significantly attenuated I/R-induced renal injury. Collectively, these findings indicate that suppressed autophagic activation in proximal Z-FL-COCHO price tubules by impaired AMPK/ULK1 signaling and upregulated mTORC1 activation underlies T2DM-induced worsening of renal… Continue reading Supplementary MaterialsSupplementary Data 41598_2017_5667_MOESM1_ESM. improved in OLETF. Treatment of OLETF with