The mechanisms where mutations in the presenilins (PSEN) or the amyloid precursor protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. important role from the -secretase complexes in the STF-62247 condition. Aside from PSEN, an adult and energetic -secretase complex includes three extra subunits: Nicastrin (Nct), PSEN enhancer 2 (Pencil-2), and either anterior pharynx… Continue reading The mechanisms where mutations in the presenilins (PSEN) or the amyloid