Compartmentalized HIV-1 replication within the central nervous system (CNS) likely provides a foundation for neurocognitive impairment and a potentially important tissue reservoir. (SGA) and phylodynamics analysis of full-length sequences, we compared CSF and blood viral populations in 33 of the 72 subjects. Independent HIV-1 replication in the CNS (compartmentalization) was detected in 20% of sample… Continue reading Compartmentalized HIV-1 replication within the central nervous system (CNS) likely provides