Endothelial nitric oxide synthase (eNOS) dysfunction induces insulin resistance and glucose intolerance. on gluconeogenesis was AMPK-dependent. Furthermore, the glucose-lowering effect and activation of AMPK by BH4 did not appear in mice with STZ-induced diabetes lacking eNOS. Consecutive administration of BH4 in mice ameliorated glucose intolerance and insulin resistance. Taken together, BH4 suppresses hepatic gluconeogenesis in… Continue reading Endothelial nitric oxide synthase (eNOS) dysfunction induces insulin resistance and glucose