Supplementary MaterialsATP binding supp data. hydrolysis (K549A), in addition to ATP analogues, was utilized showing that ADP binding by Mcm2 must inhibit DNA binding and unwinding by Mcm4/6/7. This Mcm2-mediated regulation of Mcm4/6/7 is normally independent of Mcm3/5. Furthermore, the need for ATP hydrolysis by Mcm2 to the regulation of the indigenous complex was obvious… Continue reading Supplementary MaterialsATP binding supp data. hydrolysis (K549A), in addition to ATP