Wnt proteins contain an unusual lipid modification palmitoleic acid. were rescued by exogenous addition of monounsaturated fatty acids. We propose that SCD is a key molecular player responsible for Wnt biogenesis and processing and that SCD inhibition provides an alternative mechanism for blocking Wnt pathway activation. Wnt Unc5b proteins are a family of secreted signaling… Continue reading Wnt proteins contain an unusual lipid modification palmitoleic acid. were rescued