Pregnane x receptor is a ligand-activated transcription element that regulates drug-inducible manifestation of several key cytochrome P450 enzymes and drug transporter proteins in liver and intestine inside a species-specific manner. gene activation in mouse hepatocytes. Conversely cyclic AMP-dependent protein kinase signaling has a repressive effect upon pregnane x receptor-mediated gene activation in rat and human… Continue reading Pregnane x receptor is a ligand-activated transcription element that regulates drug-inducible