Expanded endoplasmic reticulum (ER)-linked degradation (ERAD) of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase benefits from the sterol-induced presenting to ER membrane layer meats known as Insig-1 and Insig-2. the sterol-accelerated ERAD of reductase that may end up being suitable to the ERAD of various other substrates. addition of sterols brought about dislocation of ubiquitinated… Continue reading Expanded endoplasmic reticulum (ER)-linked degradation (ERAD) of the cholesterol biosynthetic enzyme