Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway that mediates the synthesis of prostaglandins from arachidonic acid. recombinant RhCMV with vCOX-2 deleted identified vCOX-2 as a critical determinant for replication in endothelial cells. Cytomegaloviruses (CMVs) are a family of ubiquitous betaherpesviruses that establish a lifelong infection within the host. Although generally benign… Continue reading Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway