Introduction Chronic lymphocytic leukemia (CLL) is one of the most typical types of leukemia, and the early diagnosis of patients coincides with their proper treatment and survival. to apply the artificial neural network (ANN) in order to identify a molecular biomarker for rapid leukemia diagnosis from blood samples?and evaluate its potential for the detection of cancer. Materials & methods The independent sample t-test was applied with the Statistical Package for the Social Sciences (SPSS;?IBM Corp, Armonk, NY, US) software on the microarray gene expression data of Gene Expression Omnibus (GEO) datasets (“type”:”entrez-geo”,”attrs”:”text”:”GSE22529″,”term_id”:”22529″GSE22529); 12 genes that had shown the highest differences (among parameters?whose p-value was less than 0.01) were selected for further ANN analysis. The selected genes of 53 patients were applied to the training network algorithm, with a learning rate of 0.1. Results The results showed a high accuracy of the relationship between the output of the trained network and the test data. The area under the receiver operating characteristic (ROC) curve was 0.991, which provides proof of the precision and the relationship with identifying Gelsolin as a potential biomarker for this research. Conclusions With these results, it was concluded that the training process of the ANN could be applied to rapid CLL diagnosis and finding a potential biomarker. Besides, it is suggested that this method could be performed to diagnose other forms of cancer in order to get a rapid and reliable outcome. strong class=”kwd-title” Keywords: artificial neural network, biomarkers, diagnosis, chronic lymphocytic leukemia Introduction Chronic lymphocytic leukemia (CLL) is a type of blood and bone marrow cancer in which uncontrolled and abnormal growth of lymphocytic cells occur. CLL is also characterized by clonal proliferation and progressive accumulation buy (-)-Epigallocatechin gallate of B-cell lymphocytes that typically express cluster of differentiation 19+ (CD19+), CD5+, and CD23+. CLL progresses slowly and every year, you can find more cases put into its list. CLL occurs often in adults as opposed to severe leukemia, that is more regular in kids?[1-3]. The survival price in CLL malignancy is significantly greater than in any other styles of malignancy, as around 83%?of the patients display a five-year survival rate, this means 83% of buy (-)-Epigallocatechin gallate patients with?CLL you live in least five years following the diagnosis is manufactured. The etiology of CLL continues to be elusive, nevertheless, it is probably that genetics and environmental elements have a significant influence on its occurrence?[4-5]. In buy (-)-Epigallocatechin gallate the karyotype experiments, del13q14, trisomy 12, del11q22-q23, and del17p13 were connected with CLL [6]. Other molecular pathologies had been within CLL, like the overexpression of the unmutated immunoglobulin large chain variable area (IGHV) genes, zeta-chain-associated proteins kinase 70 (ZAP-70), CD38 proteins, and mutations in the NOTCH1, splicing aspect 3b subunit 1 (SF3B1), and baculoviral IAP repeat-that contains 3 (BIRC3) genes. Furthermore, mutations in tumor suppressor genes, which includes tumor proteins P53 (TP53) and ataxia-telangiectasia mutated (ATM), have already been linked with levels of level of resistance to common chemotherapeutic brokers. Micro-ribonucleic acid (RNA) expression alterations and aberrant methylation patterns in genes, which are particularly deregulated in the CLL, like the B-cellular lymphoma?2 (BCL-2), T-cell leukemia/lymphoma 1 (TCL1), and ZAP-70 genes, are also encountered and from buy (-)-Epigallocatechin gallate the distinct scientific parameters. The scientific manifestations of the medical diagnosis are really diverse [7-10]. Around 60% of the sufferers are asymptomatic, and the individual could be?suspected of the condition following a routine blood vessels check. When symptomatic, sufferers show unclear outward indications of exhaustion or weakness. CLL is normally identified as buy (-)-Epigallocatechin gallate having blood tests as the cancerous cellular material are located in the bloodstream. A bone marrow biopsy is normally unnecessary to diagnose the CLL, nonetheless it could be done prior Adam23 to the start of the treatment. Lately, molecular and cellular markers have got contributed to the prediction and medical diagnosis of CLL in sufferers. As a result, the identification of crucial.
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