The annals of specific therapy for hereditary tumors goes back to middle 1980s and involves several reports demonstrating regression of familial colon polyps upon administration of sulindac. and sporadic medullary thyroid tumor. Vismodegib, an inhibitor of SMO oncoprotein, triggered regression of basal-cell carcinomas in individuals with Gorlin symptoms. Down-regulation of mTOR kinase by everolimus continues… Continue reading The annals of specific therapy for hereditary tumors goes back to
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Adolescence is a period of substantial neuroplasticity in stress NFIL3
Adolescence is a period of substantial neuroplasticity in stress NFIL3 regulatory neurocircuits. (HPA) axis in response to a novel stressor and increased immobility in the forced swim test. Blunted HPA axis responses were accompanied by reduced vasopressin mRNA expression in the paraventricular nucleus of the hypothalamus (PVN) suggesting decreased central drive. Adolescent females tested immediately… Continue reading Adolescence is a period of substantial neuroplasticity in stress NFIL3