Recent evidence suggests that Cx43 expression in glioma cells and astrocytes influences tumor cell motility independently of its channel function (192). cells delivery to dendritic cells of antigenic peptides through GJs have been associated with enhanced immune-mediated tumor elimination. In this review, we provide an updated overview on the role of GJICs in tumor immunity, focusing on the pro-tumor and antitumor effect of GJs happening among tumor and immune cells. Accumulated data suggest that GJICs may act as tumor suppressors or enhancers depending on whether tumor cells interact mainly with antitumor immune cells or with stromal cells. The complex modulation of immune-tumor cell GJICs should be taken into consideration in order to potentiate current malignancy immunotherapies. ROS transfer to the BM hematopoietic microenvironment during stress-induced hematopoietic regenerationTaniguchi Ishikawa et al. (63)Cx43- and Cx45-GJs regulate CXCL12 secretion by PD158780 BMSC and homing of HSC and leukocytes to the BMSchajnovitz et al. (70)Hemostasis and thrombosisCx37-GJIC between aggregating platelets limits thrombus propensity by downregulating platelet reactivityAngelillo-Scherrer et al. (71)Cx37 and Cx40 channels participate in platelet aggregation, fibrinogen binding, granule secretion, and clot retractionVaiyapuri et al. (72); Vaiyapuri et al. (73)Immune tolerance/Treg cell activityGJ-mediated transfer of cyclic adenosine monophosphate (cAMP) is definitely involved in Treg cell-mediated suppression of PD158780 responder T cellsBopp et al. (74)GJIC between Treg cells and DCs abrogates the induction of CD8+ T reactions during the sensitization phase of experimental CHS reactions by interfering with T cell stimulatory activity of DCsRing et al. (75)Manifestation of Cx43 in thymic Treg cell progenitors helps Treg cell developmentKuczma et al. (76)GJ-mediated cAMP transfer from Treg cell to DCs settings GvHDWeber et al. (77)Cx43-GJIC is definitely a component PD158780 of the Treg cell suppression mechanism compromised in ageing NOD miceKuczma et al. (78)Swelling/Defense cells migrationGJ coupling between neutrophils and the endothelium favors transmigration of neutrophils and modulates leakinessZahler et al. (79)Acinar Cx32-GJIC modulates the severity of acute pancreatitisFrossard et al. (80)GJs favor monocyte/M? transmigration across a BBB model. TNF-/IFN–stimulated monocyte/M?s secrete MMP-2 inside a GJ-dependent mannerEugenn et al. (81)Cx43 channels participate in atherosclerotic plaque formation Cx43 channels of triggered neutrophils modulates endothelial cell function during inflammationEltzschig et al. (85)ATP released Cx37 channels of monocytes inhibits their adhesion to the endothelium, controlling the initiation of atherosclerotic plaquesWong et al. (86)Endothelial Cx43 and GJIC allow leukocyte adhesion and transmigration during acute swelling a Cx43-GJ/cAMP-dependent mechanismMoreno-Fernandez et al. (95)GJICs mediate the transfer of cGAS-triggered cGAMP from DNA disease- or illness the release of the extracellular danger transmission UDPQin et al. (98)CNS immunityAstrocytic Cx43-GJs play a neuroprotective part during ischemia, regulating the apoptosis and the inflammatory response after strokeNakase et al. (99)Launch of glutamate Cx-HCs of triggered microglia causes neuronal death during swelling, ischemia or autoimmune encephalomyelitisTakeuchi et al. (100); Takeuchi et al. (101); Shijie et al. (102)Cx43 channels participate in the metabolic status of astrocytes during inflammationRetamal et al. (103)Astrocytes reduce apoptosis of melanoma cells treated with different chemotherapeutic medicines by sequestering intracellular Ca2+ GJsLin et al. (104)Swelling or hypoxia-induced astroglial Cx43-HC activation induces neuronal and astroglial cell deathFroger et al. (105); Orellana et al. (106); Orellana et al. (107)CNS oligodendrocytes Cx47- or Cx32-GJs loss alters the CNS immune status without external triggersWasseff and Scherer (108)Astroglial Cx43 promotes immune quiescence of the brain, through establishing the activated state of cerebral endothelium, which settings the immune cells recruitment and Ag demonstration mechanismsBoulay et al. (109)Carcinoma-astrocyte Cx43-GJs promote mind metastasis by PD158780 cGAMP transferChen et al. CIP1 (110)Lung malignancy cells acquired pro-survival miRNAs from astrocytes inside a GJ-dependent mannerMenachem et al. (111)Mucosal immunityGJs coordinate ciliary beating in respiratory mucosa airway cellsSanderson et al. (112); Boitano et al. (113); Homolya et al. (114)Cx43-GJs spread Ca2+-dependent pro-inflammatory signals in the lung capillray bedParthasarathi et al. (115)LPSSarieddine et al. (120)illness induces Cx43 manifestation and Cx43-HC opening in the apical membranes of infected colonocytes,.